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KMID : 0366220120470040302
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Korean Journal of Hematology
2012 Volume.47 No. 4 p.302 ~ p.306
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A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia
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Jin Sun-Mi
Jang Moon-Ju
Huh Ji-Young
Park Myoung-Hee
Song Eun-Young
Oh Do-Yeun
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Abstract
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Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurring after transfusion of platelet concentrates in a patient with acute leukemia. Although most patients with TRALI show improvement within 48?96 hours, our patient’s condition rapidly worsened, and he did not respond to supportive treatment. TRALI is a relatively common and serious adverse transfusion reaction that requires prompt diagnosis and management.
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KEYWORD
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Transfusion-related acute lung injury (TRALI), Transfusion, Anti-human leukocyte antigen (anti-HLA) antibody
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